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KMID : 0358419970400030606
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Korean Journal of Obstetrics and Gynecology
1997 Volume.40 No. 3 p.606 ~ p.613
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Correlations amongst Insulin-like Growth Factor-I(IGF-I), Insulin-like Growth Factor Binding Protein-3(IFBP-3), Growth Hormone(GH) and Estradiol(E2) in Follicular Fluid of the Patients with Ovulation Induction
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이용주
배상욱/정창진/김동현/장경환/이병석/박기현/조동제/송찬호
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Abstract
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Recently, the ovary is known to be a center of paracrine and autocrine regulating factors.
IGF-I is a local regulator of follicular function and a potent stimulator of ovarian cell proliferation and differentiation, in synergy will the gonadotrophins, whilst GH may exert its effect by changing intra-ovarian IGF-I concentration. In
biological
fluids, IGFs are bound to specific, high affinity binding proteins(IGFBP0. The IGFBPs are considered as paracrine modulators of the action of IGF-I in the ovary.
The aim of the study is to elucidate relationships amongst IGF-I, IGFBP-3, GH and estradiol in mature follicular fluids or serum. Thirty-six infertility patients who underwent ovulation induction program by GnRH agonist short or long protocol for
in
vitro fertilization (IVF) were examined to investigate the correlations amongst the concentration of IGF-I, IGFBP-3, GH and estradiol in follicular fluid or serum. These hormones were quantitatively analyzed by radioimmunoassay(RIA) of
Immunoradiometric
assay(IRMA). There were statistically significant correlations between the concentration of IGF-I and GH, IGFBP-3 in follicular fluid.
Therefore, GH tends to increase IGF-I levels in follicular fluid and IGF-I may functions as an important regulator of IGFBP-3 synthesis in follicular fluid, but IGFBP-3 is not likely to be under the direct control of GH in follicular fluid.
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